Know Your Ovaries to Know PCOS

Know Your Ovaries to Know PCOS

Though in India we have 5 in 10 women suffering from PCOS, the awareness about the condition is at its lowest in the country. Lack of basic understanding of the condition and the biological function of the ovaries often creates fear and chaos among the patient. Having brief guidance on how female reproductive organ works and how an imbalance in the hormonal levels results in conditions like PCOS can help in overcoming the chaos and myths associated with the disease. Not only this but it will also help to educate women and create a broad range of awareness. To begin with, this article will focus on briefly guiding the structure of ovary, their function, and their role.

Understanding the ovaries

It’s the primary sex organ in females which is connected with uterus with the help of ovarian ligaments. The ovary has three protective layers which include outer germinal epithelium, inner tunica albuginea, and innermost ovarian cortex, where ovarian follicles are located and the development of follicles takes place.

Before birth

The process by which the female gamete (egg) is produced is known as oogenesis. It starts during fetal development when primordial cells / primitive cells (The initial cells) migrate from the yolk sac to ovaries where they differentiate to form oogonia which divide through a biological process of mitosis to produce millions of oogonia or primary oocyte. Now primary oocytes get arrested in prophase of cell division until puberty is attained.

At puberty 

Each month after puberty until menopause, gonadotropin’s i.e. FSH (Follicular Stimulating Hormones) and LH (Luteinising Hormone) are secreted by the anterior pituitary gland. FSH induces the development of ovaries, which in turn produce the hormone estrogen (Female sex hormone). This hormone is responsible for the development of secondary female sexual characters.

Oogenesis

The formation of an ovum is called oogenesis which occurs in the ovary. Oogenesis occurs in 3 steps: Multiplication, Growth, and Maturation.

Multiplication phase: In fetal development, certain cells in the germinal epithelium of the ovary of the fetus are larger than others. These cells divide mitotically producing millions of oogonia. Oogonia multiply mitotically forming primary oocyte then get surrounded by the primary follicle.

Growth phase: This phase occurs for a very long time in which the primary follicle grows by taking food for surrounding follicles.

Maturation phase: Each primary oocyte undergoes two meiotic divisions. In the first meiotic division, one big haploid secondary oocyte and a very small first polar body are produced. In the second meiotic division, secondary oocyte divides into big ootid, which later matures into the ovum, and the first polar body divides into two smaller polar bodies. Polar bodies do not take part in reproduction.

Menstrual cycle

The cycle completes itself in 28 days. Menstruation is bleeding from the uterus of adult females. It begins at the age of 13 years generally and continues until about 45 to 50 years.

Follicular phase: This phase usually lasts for 10 to 12 days. The follicular stimulating hormone (FSH) secreted by the anterior lobe of the pituitary gland stimulates the ovarian follicles to secrete estrogen. In this phase, the production of FSH and estrogen increases. Oestrogen stimulates the proliferation of the endometrium of the uterus wall by making it thick and increases in uterine glands and vessels.

Ovulatory phase:  Both FSH and LH ( luteinizing hormone) attain its peak level in the middle of the cycle and on the 14th day, the rapid secretion of LH induces the release of secondary oocyte which is arrested at its metaphase of meiosis II, from the ovary.

Luteal phase: This phase lasts for 10 to 12 days after ovulation. When the secondary oocyte leaves ovary the remaining part of ovarian follicle secretes LH to develop corpus luteum, which starts secreting progesterone. Progesterone is very essential for maintaining thick uterus lining for implantation of the embryo if fertilization occurs.

Menstrual phase: If fertilization does not occur, production of LH is reduced which results in the degeneration of corpus luteum. No corpus luteum means the production of progesterone is reduced. This results in the disintegration of endometrium and blood vessels. Thus menstruation begins with all the endometrium secretions, blood vessels and unfertilized egg coming out of the vagina as menstrual flow. Blood clotting here does not occur due to the presence of fibrinolysis. Those last for 3 to 5 days.

Hormonal control

Gonadotropin-releasing hormone (GnRH) is secreted by the hypothalamus which stimulates the pituitary gland to release LH and FSH.

FSH: Stimulates the growth of follicles inside ovary and also the development of oocyte within the Graafian follicle to complete the meiosis I to the secondary oocyte. FSH also stimulates the production of estrogen.

 LH: Induces ovulation and formation of corpus luteum which in turn release of progesterone. The rising level of progesterone inhibits the formation of GnRH, which in turn, inhibits the production of FSH and LH and progesterone.

The entire reproductive cycle is mainly governed by the complex interplay of hormones. Any imbalance in the hormonal level impacts the entire cycle altering the reproduction leading to infertility and conditions like irregular periods. These are some of the basic symptoms of PCOS conditions that occur mainly due to the hormonal imbalance, a result of poor lifestyle, unhealthy diet, exposure to environmental factors like xeno-estrogens and more. So, if you are suffering from any of the above symptoms mentioned please do check with your doctor and follow a healthy lifestyle to bring back the balance because remember PCOS condition can be healed with the right guidance. If you have any queries about the condition, feel free to connect with our experts.

Why It Is Quite Difficult to Lose Weight for Women With PCOS?

Why It Is Quite Difficult to Lose Weight for Women With PCOS?

Increased weight condition is very common to women suffering from PCOS. Some studies suggest that half of the women with PCOS are overweight, who are recommended by doctors to lose weight to reduce the impact of lifestyle diseases. If you are also suffering from overweight issues due to PCOS then you must know how difficult it is to maintain a healthy weight. Let’s understand why some women with PCOS, face extreme difficulty in weight loss while others don’t.

Your Body Is Storing a Lot of Fats…

Excess of insulin production in the body causes your body to switch into fat storage mode making weight loss process difficult. Insulin is a hormone that is produced by the pancreas in your body in response to the availability of glucose in the bloodstream. The insulin helps in the transport of glucose in the bloodstream to the cells of your body, where it can be converted into energy to perform basic cellular functions.

Under the PCOS condition, the normal secretion of insulin in response to glucose is altered leading to insulin-resistant, wherein our cells become resistant to insulin. This signals the pancreas to produce more insulin. Excess of insulin pushes the body to go into fat storage mode leading to weight gain. This is the reason most of the treatment options for PCOS management depend on balancing insulin levels through diet and exercise modifications or in some cases through supplementation.

Increased Appetite and Craving…

If you experience frequent hunger or cravings for sugary food then blame it to your imbalanced insulin levels. An increase in insulin resistance turns your body into high appetite mode. The reason is insulin is an appetite-stimulating hormone, more the levels- more you feel hungry. This is the major reason that females with PCOS find themselves craving for food more often than others. If these strong, instant cravings are not managed effectively, it can lead to high-calorie consumption and weight gain. To prevent this, nutritionist suggests opting for frequent healthy meals rich in protein and avoiding sugary foods.

Insulin Is Not The Only Culprit…

Though insulin is one of the crucial appetite-stimulating hormones, there exist many other hormones that influence satiety and appetite. Hormones like leptin, ghrelin, cholecystokinin are some of the common appetite-stimulating hormone known to influence appetite levels. Any kind of imbalance in the hormones stimulates hunger in women with PCOS in a manner similar to insulin regulation. This, in turn, leads to increased intake of food causing extensive weight gain. You can manage the hormonal balance by following a comprehensive diet and exercise routine.

Diet with Low Glycemic Index…

If you following a proper diet and still facing difficulty in managing your weight then you must check for the components you are eating. A study was conducted between two groups wherein they were given the same food with the same calories and equal distribution of macro & micronutrients but different glycemic index. It was observed that people consuming food with a low glycemic index experienced better weight loss in comparison to those consuming diet with a high glycemic index.

Check for obstructive sleep apnea…

Another major cause of weight gain among women with PCOS is obstructive sleep apnea. This condition occurs when there is any kind of blockage in the airways which limits the availability of oxygen while sleeping. This later causes day sleepiness, imbalanced blood pressure levels, and weight management issues. In addition to this, imbalance in the levels of androgens also impacts weight management in women with PCOS. Some studies show that high levels of androgens often affect the sleep receptors leading to severe sleep apnea.

If you are suffering from PCOS conditions and facing difficulty in managing weight even after putting a lot of efforts then you must consult your doctor. There is a need for improvising your diet and exercise routine to enhance the weight management process. We at Genetic Healing have a team of experts who can help you devise a highly impactful diet and exercise program for weight management. Feel free to seek a free consultation today itself to gain better insight.

 

 

 

Unlocking the secret to “Your PCOS Diet”

Unlocking the secret to “Your PCOS Diet”

Unlocking the secret to “Your PCOS Diet”

Diet is the primary concern to resolve in women suffering from PCOS condition. You can also consider it as the default option that almost every doctor or health expert will suggest you consider. And why not, PCOS is a lifestyle disease majorly contributed by hormonal imbalance due to altered lifestyle, environmental exposure or genes. Let’s learn how diet can play a critical role in overcoming the menace of PCOS and what is “Your PCOS diet”?

As soon as someone talks about diet, we often think of it as a strict regime that is hard to follow and make you starve. But in reality, diet is not something that stops you from eating. Instead, it allows you to eat what you want but in an organized and proportionate manner. Similarly, as you must have guessed from the name, the PCOS diet is specifically for women facing critical symptoms of the condition. You can consider it as a comprehensive nutritional plan structured as per the personal goals and conditions to get the best outcome.

PCOS diet can be considered as a personalized diet, prepared according to your likes, dislikes and nutritional requirement of the body to help bring back the hormonal balance. If you consider the common reason for PCOS among the girls of childbearing age then it is mainly unhealthy eating habits and poor lifestyle. Imbalance in the intake of micro and macronutrients alters the underlying biological pathways, which later indirectly disrupts the estrogen balance. This is why it is of key importance to have proportionate nutrition on the plate in terms of Proteins, Carbohydrates, and Fats.

If you are struggling with the issue of PCOS for long and finding difficulty in managing it then you must connect to our nutrigenomics counselors. At Genetic Healing, we have catered to many women facing difficulty in overcoming the challenges associated with PCOS. We follow a novel approach of gene testing that identifies the key reason responsible for hormonal imbalance in your body. This includes assessing genes playing role in Phase I/II detoxification pathway, carbohydrate metabolism, estrogen metabolism and much more. A thorough understanding at the genetic level allows our team to prepare a comprehensive exercise and PCOS diet plan for you. It follows simple and easy to follow remedies and daily food habits that you can stick to diligently, giving sustainable results. To know more about the PCOS diet, connect with our experts to seek a free consultation. The team will help you guide about the same, making your journey to overcome PCOS effortless and achievable.

Understanding Hair Loss and PCOS

Understanding Hair Loss and PCOS

If you or anyone close to you is suffering from PCOS then you will observe that hair thinning and subsequent hair loss is a very frequent problem. But do you know why does it happen? Why this problem becomes very severe in cases of women or girls suffering from PCOS condition? Well, the answer to this lies in your genes!

Genes and follicle sensitivity

Various scientific studies reveal that hair thinning is mainly caused by a genetic condition, which is inherited from either of the parents. In this condition, the follicles of the hair become sensitive to the androgens in the body. Though we all have these follicles, only a few of us show such reactive behavior in response to high androgen levels. Androgens are nothing but hormones present in all of our bodies. It is known to be predominantly present among men, often known as the male hormone. However, it is also present in a small ratio among women. Follicles sensitive to androgen, triggers the thinning response of hair, eventually leading to hair loss. This reduces the volume and length of your hair, eventually making your scalp more visible.

We all know that women with PCOS have an imbalance in hormonal levels. This often leads to high levels of androgen in the body triggering the follicle sensitivity to androgen. In women with little or no follicle sensitivity, hair may not be affected to an extent seen in women with sensitive follicles.

Is there a way?

It is very evident from the above understanding that women with PCOS will be prone to hair loss if they exhibit follicle sensitivity. The question arises – Is there a way? Can we overcome this issue? Is there any possible treatment that can slow down or manage the condition better? Well, the answer to this is yes. Here are some of the common treatment methods suggested by experts to overcome hair thinning and hair loss issues. However, always seek the advice of your concerning doctor and healthcare expert before undertaking any of these treatments.

Using Anti-Androgens:  One of the common treatments for reducing hair loss issues due to androgen sensitivity is to use anti-androgen. They are available both as oral and topical solutions. In severe conditions, it is suggested to use both oral and topical solutions for better results. the oral pills like Dianette, Spironolactone, and Yasmin are commonly suggested by doctors for women with PCOS. In the case of topical solutions, doctors suggest using a combination of both anti-androgens and hair follicle stimulant.

Healthy diet: If you are looking for a long-term solution then it is very important to consider lifestyle changes. One of the key points to note here is to bring significant changes to your eating habits. This includes skipping unhealthy food like oily snacks, junk, etc, and switching to healthy ones like green veggies, fresh fruits and more.

Regular exercise: Hormonal imbalance is the major cause of the PCOS condition and subsequently hair loss. Performing regular exercise such as cardio, walk, strength or as simple as meditation and yoga can bring significant improvement. These exercises help to maintain homeostasis in the body by channelizing positive changes. This includes creating a balance of biomolecules and biochemicals in the body, reducing the production of oxidative compounds like free radicals (A major cause for hair loss).

We know that PCOS brings a lot of complications into the life of the person suffering from it. But if one starts to take hold of their life and work upon healthy lifestyle changes, managing the PCOS condition becomes easy. So, start working upon your daily routine step by step and you will be able to see significant improvement.

Emotional counselling and PCOS

Emotional counselling and PCOS

If you are close to someone having PCOS, you will be very much aware of the emotional distress one suffers from. It is one of the major concerns among women suffering from PCOS because most commonly doctors look at the physical symptoms of the disease and not the emotional or mental stress. Though it may seem a little daunting to you, there is nothing much to be worried about if you understand the condition properly. Here in this article, we are sharing some insights, which can help you or your loved ones overcome the emotional distress and live life like normal.

Researchers at Cardiff University studied the history of more than 17,000 women with PCOS. The study showed that there are high chances of women with PCOS to be diagnosed with a mental condition such as depression & anxiety in comparison to those who don’t have PCOS. This is the reason one needs to focus on both physical as well as mental condition when suffering from PCOS. The good thing is – This condition can be managed easily with mindfulness.

Identifying the low…

The foremost step to managing emotional distress condition is to recognize when you are into one. It is very easy to fall into the trap of distress if we don’t recognize where to stop. Therefore, identify the point where you feel low or down and take initiatives to let the negative thought stop. Nowadays, many of the clinical processes for PCOS also involve psychological tests that help evaluate the mental and emotional distress in the patients. The most common questions in this test will be:

  • For past how many months/days you are feeling low, down or depressed?
  • During the last month, have you often been bothered by having little interest or pleasure in doing things?

If you find the answer to both of the above questions is ‘Yes’, then you probably need to consult a doctor immediately. The later you approach the doctors, the more time it will take for recovery.

Stay healthy for a healthy mind…

It is often said that “We Are What We Eat” and it stands true. Eating healthy food and doing regular exercise helps to maintain a balance of hormones in the body. This not only includes hormones involved in PCOS conditions but also those important for happy mood such as dopamine, serotonin and more. Moreover, following regular exercise keeps you engaged, increases social involvement and helps you maintain your weight.

Unlock the new learnings…

One of the best ways to help yourself is to understand what exactly you are going through. For this, you need to read more about the emotional distress situation in PCOS or consult a good doctor/counselor. Knowing and understanding whether you are in stress or depression is key to finding the right solution. This is so because there exists a very thin line between being stressful and being in depression. There might be a situation showing symptoms of depression but you are ignoring considering it as stress. If avoided for long, it can lead to severe mental health issues which might become difficult to resolve.

Practice mindfulness…

Another way to subside emotional distress in PCOS like conditions is to practice mindfulness. Help yourself by learning how to relax your mind with the help of meditation. All you need to do is to spend some quality time focusing on your breath, keeping your eyes closed. This not only calms down your brain and body but also increases the power to concentrate and think mindfully. Meditation is considered to be one of the best ways to overcome any kind of mental health issue. Nowadays, many kinds of research show that practicing regular meditation along with healthy food & timely exercise can revert emotional distress conditions.

PCOS is a condition where women across the globe lack knowledge and understanding of how to deal with it. There is a lot of gap in understanding what exactly the disease is, how it can be managed effectively and what one should do? Though there is a plethora of information available online, we will suggest you support that information with the knowledge of some experts. If you find your condition severe, consult your doctor or a counselor. PCOS is often considered a taboo among women. Well, it is not. Just like some other lifestyle disease, PCOS is also easily manageable. If you are still in any query feel free to connect with our team. Our PCOS Support Program is targeted towards helping women know the right steps and solutions to overcome the menace of PCOS. Let’s not fear about the condition because, with requisite lifestyle changes, one can live a normal, happy life.

How Meditation Can Help in PCOS?

How Meditation Can Help in PCOS?

HOW MEDITATION CAN HELP IN PCOS

We are not unknown with the fact that healthy habits are the need of time. Thanks to the changing way of life that is leading to lifestyle-associated diseases such as PCOS. This is the reason that the wellness industry is coming ahead to help people overcome the menace of lifestyle disorders such as diabetes, cardiac issues and more. This even stands true for those suffering from a hormonal disorder like PCOS. For women with PCOS, support like regular meditation is considered paramount in reversing the symptoms of PCOS.

Many people raise questions on the effectiveness of meditation in PCOS, this is due to the lack of significant awareness among people. Moreover, meditation is known to cure the symptoms indirectly by regulating the biochemical components at different levels in our body. However, some studies highlight the importance of meditation in overcoming the symptoms considerably among women. Let’s unfold this and understand in more detail how meditation helps in PCOS.

Helps maintain blood glucose levels…

Meditation helps your body to relax, which can indirectly improve the sensitivity to insulin receptors. This helps in regulating the excess of glucose in the blood-stream and controlling sudden erratic peak in the blood sugar levels. Many studies are in pipeline which suggests that meditation and yoga if performed regularly can help women keep disease like PCOS away. Specifically, when it comes to healthy blood sugar levels, regular meditation also helps to keep you at distance from other associated diseases like type-2 diabetes, weight issues, Alzheimer’s and more. One such study implicating the role of meditation in insulin sensitivity has been published in the North American Journal of Medical Sciences.

A better immune system…

It is very prominent that a better immune system helps protect us from the biochemical initiators of disease. However, it is also very evident from various studies that conditions like stress, lack of exercise, unbalanced diet, etc can turn down the immune system, making it difficult to curb the debilitating symptoms of diseases like PCOS. There have been research studies which indicate that meditation can have a profound positive impact on women suffering from PCOS. Though there are many reasons for this, one of the crucial reasons is it curbs the stress, which is considered to be the major cause behind the weakening of immune system functioning.

Improved digestive system…

Most of the women with PCOS are also known to be diagnosed with poor bowel system. This happens mainly when the digestive enzymes do not work at their optimum leading to improper digestion. Research studies have shown that regular meditation exercise helps digestive enzymes to work at their optimal rate. This happens because meditation helps to activate the Parasympathetic Nervous System (PNS) of your brain. Whereas, in the absence of meditation and presence of stress conditions, the Sympathetic Nervous System (SNS), also known as stress systems gets activated. PNS helps the body to recover from the damage caused due to stress by promoting restorative activities. This helps to reduce the harmful oxidative species in the body generated due to stress which forms the major cause for many of the symptoms of PCOS.

PCOS is a condition of hormonal disorder which occurs mainly due to an imbalanced lifestyle. To bring significant changes and overcome its symptoms, regular meditation can be of great help. This is the reason many PCOS experts and counsellors suggest women to perform regular yoga and exercise like meditation. It calms and relaxes the body, bringing the internal biological system to normalcy and homeostasis. So what are you waiting for? If you or your loved ones are suffering from PCOS, do suggest them for regular meditation. Move ahead today, to prevent the struggles of tomorrow.

Exercise in Polycystic Ovarian Syndrome (PCOS)

Exercise in Polycystic Ovarian Syndrome (PCOS)

Polycystic Ovarian Syndrome (PCOS) is known to be one of the common lifestyle diseases prevalent among the females of childbearing age. The symptoms of the condition can vary from being very severe like hirsutism to very mild like acne, weight gain and more. There is no doubt that woman with PCOS finds difficulty in coping up with these symptoms. Instead, many of the women in India even don’t know what exactly PCOS is and how one can overcome it? Many scientific studies show that lifestyle conditions like PCOS can be controlled by bringing lifestyle modifications such as regular exercise, a healthy balanced diet, yoga and more. For long, an exercise in Polycystic Ovarian Syndrome (PCOS) has been considered very effective as it helps subside its potent symptoms. In this article, let’s discuss more the role of exercise and how does it impact the women with PCOS.

Scientific Research Showing Effect of Exercise

There has been a lot of research by scientists to understand the effect of exercise among women with PCOS. In one such research published in the Asian Journal of Sports Medicine, scientists tried to study the prevalence of PCOS in women who perform exercise regularly with those who don’t. The study showed that regular exercise as simple as walking helps to control PCOS symptoms like diabetes, homocysteine levels, cardiovascular risk, weight gain and more.

Extensive studies have proved in various cases that PCOS demonstrates metabolic features such as increased levels of insulin secretion and resistance leading to diabetes, abnormal cholesterol levels and free plasma lipids, which can lead to cardiovascular risks. Knowing the true culprit behind the PCOS is still a mystery to be unfolded. However, researchers believe that it is mainly due to an imbalance in the levels of reproductive hormones like androgens. For this, lifestyle plays a very crucial role because an ineffective and sedentary lifestyle can lead to obesity issues, insulin resistance and more, which in turn causes an imbalance in androgen, making the clinical features of PCOS very much evident among women.

How Does Regular Exercise Impact?

Regular exercise helps in improving body metabolism leading to significant weight reduction over a period of time. This leads to reduced glucose intolerance, improving the balance of hormone and other associated biological factors in the body. Studies have shown that regular exercise helps in overcoming the irregularity in the menstrual cycle and ovulation among 50% of women diagnosed with PCOS. The reason is, exercise brings positive changes at the metabolic level, which maintains the controlled released of luteinizing hormone and thus preventing over secretion of androgens.

Exercise is also known to modulate insulin resistance and lipid metabolism in skeletal muscle by enhancing the much-needed triacylglycerol levels in the cells. Likewise, regular exercise is known to enhance various biological factors such as capillary density, mitochondrial density, hyperplasia of muscle fibers, neural sensitization, motor learning, and much more. All these factors comprehensively promote positive outcomes among women with PCOS. This is the reason almost every doctor suggests undertaking regular exercise sessions along with a healthy balanced diet.

If you or your loved ones are facing the issue of PCOS then it is high time you take charge of your body and overcome associated challenges. One of the best ways is to connect with experts who can guide you throughout your journey of overcoming PCOS. At Genetic Healing, we have a team of professional experts having years of experience and knowledge in PCOS management. To know more connect with them and kick start your journey to overpower menace of PCOS.

Insulin Resistance and Associated Genes

Insulin Resistance and Associated Genes

Insulin resistance is a very complex condition wherein a multitude of factors play a key role. There are intricate metabolic pathways and traits involved which govern the condition. Besides this, environmental and genetic factors are also a key component in the advent of insulin resistance conditions. For long, studies have been carried out to gain better insight into the health implications and underlying genetic factors. The genome-wide association studies have provided a lot of advancement in unveiling the genes behind the insulin resistance condition. There is no doubt that such huge studies would have brought multiple gene variants in the forefront that guide conditions like insulin resistance. However, in this article, we will highlight only some of the most common genetic variants having a profound impact on the condition.

Genes like TCFL2, PPARG, FTO and more are widely known to be involved in insulin resistance conditions. For this, the genes are present with one of three common types of allele variants. These mutations (or variants) in the genes alter their normal functioning leading to an imbalance in metabolic functioning and especially in pathways like insulin, glucose, and lipid metabolism. Let’s gain a better understanding of individual genes and subsequent mutation leading to insulin resistance conditions.

TCFL2 (Transcription factor 7 like 2) gene

TCFL2 gene encodes for a transcription factor which plays a key role in regulating the blood glucose balance. Any alteration in the gene encoding this factor can hugely impact this glucose homeostasis in the body of an individual leading to increase susceptibility towards insulin resistance. This mainly occurs when there is C to T variation in the gene. Therefore, individuals with TT genotypes for the TCFL2 gene will have a high risk of insulin resistance. This is known to occur mainly in response to saturated fat and not carbohydrate ingestion. An individual with a bad variation in TCFL2 also faces difficulty in weight loss. Hence, such individuals are suggested to undertake a hypo calorie and low-fat diet along with the requisite exercise regime.

FTO (Fat Mass and Obesity) gene

FTO gene is known to play a crucial role in regulating appetite, energy intake, and expenditure. Alteration in the gene encoding for FTO is known for predisposition to health conditions like insulin resistance and obesity. This mainly occurs when an individual carries T to A variation in the FTO gene. As a result of this, people with an A allele suffer from increased BMI (Body Mass Index), body fat percentage, waist circumference. Besides this, individuals with such mutations are known to be highly susceptible to insulin resistance and diabetes due to high fat intake.

PPARG (Peroxisome Proliferator-Activated Receptor) gene

PPARG gene encodes for the protein receptor which plays a role in fat metabolism within a cell. This protein is produced abundantly within fat cells and is important for the production of new fat cells. Any mutation in the gene can lead to reduced BMI and obese conditions due to reduced efficiency of the protein. This gene has three variants due to C to G alterations. Individuals with genotype CC are considered to be highly sensitive to the type of fat intake which leads to obesity and insulin resistance. Whereas, the genotype with G variations are considered to be good as they have low sensitivity towards the fat.

Like TCFL2, FTO and PPARG there are other genes such as ADBR, VDR, FABP2, HLA DQ, and more which govern the increased sensitivity towards insulin. This over a period of time if ignored can lead to diabetes or insulin resistance. That’s why knowing your genes with genetic testing, helps you know about your condition better. This way an individual can chart out their lifestyle and associated habits to prevent the predisposition to any such health issues. This becomes very critical in conditions like insulin resistance associated with PCOS, wherein females suffer hormonal imbalance leading to impaired metabolic performance.

Understanding the Link Between PCOS and Insulin Resistance

Understanding the Link Between PCOS and Insulin Resistance

Do you know PCOS and insulin resistance are interlinked? Statistics reveal that 30-40% of females with polycystic ovary syndrome (PCOS) also suffer from insulin resistance. The question is why both these conditions are interlinked? What are the symptoms that dictate the presence of insulin resistance among women with PCOS? In this article, we will try to address some of these questions and gain better insight into the link between PCOS and insulin resistance.

Insulin resistance is a condition wherein the body cells do not respond to secreted insulin, which leads to increased levels of glucose. If ignored for a long time, it can also lead to pre-diabetic conditions or type 2 diabetes. In some cases, insulin resistance can be the major root cause of PCOS and vice versa. The condition is also known to aggravate the symptoms of PCOS. Just like PCOS treatment, insulin resistance requires lifestyle modification and medication support. Moreover, to detect the condition early, every female with PCOS must be screened for insulin resistance.

Gaining some deeper insights

Insulin is produced in our body by the pancreas, a gland present in the abdomen region. The secretion of insulin takes in response to a hike in glucose levels in the blood. The sugar molecule enters into our blood after 15-20 minutes of intake of carbohydrates rich food. The presence of insulin helps the cells in our body to take up the glucose molecules and convert them into energy for further metabolic use.

Under insulin resistance conditions, the cells in our body do not respond to secreted insulin leading to a rise in blood glucose levels and low energy production. This condition later leads to diabetes as our body starts to deal with increased levels of glucose differently.

Understanding the link

It is a well-proven scientific fact that over a time PCOS condition increases the risk of developing diabetes. Despite the known fact that PCOS symptoms arise far earlier than that of insulin resistance, it is also believed that insulin-resistance might also play a crucial role in the onset of PCOS condition, rather than the other way around.

The increased level of insulin is one of the major factors behind inflammation and other metabolic conditions associated with PCOS. Though scientists know that there exists some connection between these two conditions, the actual cause of the link between two is yet to be unfolded.

Well, if you are thinking that insulin resistance affects all women with PCOS similarly then you are wrong. It does not have the same effect on all women, in some cases, it may lead to severe complications while in other cases it might not affect at all. As per some studies, it is suggested that obese condition is associated with insulin resistance which in turn impacts the functioning of hypothalamus and pituitary glands in the brain. These two glands are very crucial for the production of androgenic hormones, which increases in such conditions leading to PCOS. Imbalance in hormonal levels is often responsible for conditions like infertility, ovarian dysfunction, irregular menstruation and hirsutism among females with PCOS.

Likewise, changes in hormones due to insulin resistance often interfere with proper implantation of the embryo, supply of appropriate nutrient & energy to the fetus and much more, which impacts the overall growth of embryo leading to miscarriages and infertility. Moreover, having insulin resistance during pregnancy also increases the risk of gestational diabetes, which is very common among women with PCOS.

The associated symptoms

Symptoms of insulin resistance are similar in women who have PCOS and those who don’t. Women with PCOS need to be aware of these symptoms because of the strong correlation between the two conditions. The first common symptom observed changes in the appetite of the females. The insulin hormone is also a great appetite stimulant, which can be considered a major reason among women in PCOS for frequent cravings. This, in turn, leads to the secretion of other associated biomolecules which increases the craving for carbohydrate-rich food. This if continues in the long term leads to excessive weight gain and obese conditions. Moreover, it also increases the future risk of cardiovascular diseases, diabetes, and arthritis. A second common symptom of insulin resistance is a pre-diabetic condition. Here you will face a frequent hike in glucose levels post intake of carbohydrate-rich food. This often leads to tingling like feeling in feet, blood pressure imbalance, frequent urinations, thirsty and more.

The above-mentioned points highlight the importance of undertaking treatment for insulin resistance and PCOS. The brief understanding shows a certain relation between both these conditions. Though some scientific evidence is available, further research studies are needed to comprehensively explain the link. Researchers across the globe are working in this direction. Until then, follow the doctor’s recommendation along with a comprehensive diet and exercise plan. Since both the conditions are lifestyle-associated conditions, bringing significant improvement in lifestyle can help overcome the menace of PCOS.

PCOS And Celebrities- Breaking The Stigma Of PCOS

PCOS And Celebrities- Breaking The Stigma Of PCOS

 Though efforts have been made to create awareness about PCOS, there still exist some gaps where the stigma of PCOS is broadly prevalent. The question is what are the reasons that women suffer from such stigma? Is it a lack of awareness or misinformation in society or anything else? Well, the following article will help you get the answer to these questions. The article highlights some of the celebrities who have suffered from PCOS and have come to the limelight to be a beacon of hope. They have not only opened up about their condition but have also paved a path of hope for other women’s suffering from PCOS.

PCOS (Polycystic Ovary Syndrome) is known to affect one in five women in India. Though considered to occur mainly in girls of childbearing age, the risks are equally prevalent from the start of menstruation till menopause. In our earlier article Future risk of PCOS due to ignorance, we highlight the outcomes of ignoring PCOS symptoms and its timely cure. You will come to know that women suffer from a high risk of developing diabetes, cardiovascular disease, cancer, depression and much more.

Celebrities Step Up To Bring a Real Impact 

Though PCOS is a common lifestyle disease, many women still are unaware of it. The main reason for this is the common symptoms of PCOS which can be often misunderstood. As per some experts, up to fifty percent of females suffering from PCOS are not effectively diagnosed with it. This is the reason most women end up diagnosing PCOS at a very late stage specifically in conditions like infertility. Different conditions intensify this difficulty. PCOS indications, for example, the overabundance of facial hair, skin break out, weight increase can make ladies feel disgraceful, humiliated and obscured. PCOS patients frequently question their mental self-portrait and conviction, which may keep them from discussing what is befalling their bodies.
PCOS condition is one of the most vital, underserved, under-analyzed and under-financed conditions influencing the wellbeing of females. Therefore, we need the strong support of media, government organizations and financing institutions to improve awareness and outreach of PCOS knowledge among women.

So when celebrities venture up to recount to their tales about PCOS, they can have a genuine and profound effect in decreasing the stigma of PCOS. Let’s discuss some of the common celebrities highlighting their PCOS journey in the most amazing way.

Harnaam Kaur 

Now an Instagram star, Harnaam once suffered from the stigma of PCOS in her early stage of diagnosis. But soon after becoming a Sikh at 16, she embraced her culture and tradition and allowed her hair to grow long. But unlike normal females, she faced the issue of excessive hair growth due to the high level of testosterone hormone, a common symptom of PCOS. However, Harnaam very well embraced her condition and took a step ahead to speak up about it. She has now become a spokeswoman for a multitude of positive movements helping women with PCOS.

Sara Ali Khan

Who doesn’t know the budding star of the Bollywood – Sara Ali Khan. Recently in an interview on ‘Koffee with Karan’, Sarah revealed her struggle with PCOS. Without thinking about any stigma she shared her story of being obese (96kgs). However, she embraced the condition and worked hard to overcome it by following a healthy lifestyle. She significantly changed her diet and exercise routine which later on helped her lose the extra kg. Today we all are aware of her charm and attractive personality which leaves behind the struggle of PCOS.

Sonam Kapoor

Another well-known actor of Bollywood who came in limelight to share her story of PCOS is Sonam Kapoor. She has been a National Award Winning actress and has shared her story very frankly to break the stigma associated with PCOS. In many interviews, she explained about her journey of fat to fit. She has revealed the struggles of PCOS she faced and how she dealt with it, along with other associated issues such as starvation, depression, excessive weight gain and much more. She even revealed that she had excessive hair growth on her face and suffered from diabetes. However, with proper lifestyle and guidance for PCOS management, she was able to control the menace of PCOS.

Victoria Beckham

A well-known fashion designer and amazing singer – Victoria Beckham has always been at the forefront to stand-up against the stigma of PCOS. She never kept her illness of PCOS a secret and has shared about its effects on her fertility. In many interviews, Beckham has shared her journey of overcoming the ill effects of PCOS. She transformed her life by following a healthy lifestyle such as a healthy diet and regular exercise.

Daisy Ridley

Are you a fan of Star Wars? Then you must be knowing the famous actress Daisy Ridley. The actress has not stepped backed and has made a profound impact by sharing about her PCOS journey on social media. She took this step on her Instagram where she shared about the severe acne symptoms she suffered during PCOS. You will find that even she advocates healthy lifestyle for effective management of PCOS condition.

The only learning we can take from these live examples is to sideline the stigma of PCOS and make a shift towards a healthy lifestyle. In our earlier blogs, we have shared why and how changes in your diet and exercise pattern can help in reversing the menace of PCOS. Just remember that you are not alone in this struggle. There are many such women’s and many of them have successfully overcome the struggle of PCOS. You can too! To know more about it you can even contact our counselors and seek free pre-test counseling. Give a kick-start to a healthy life and say no to PCOS struggles.

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