CLOCK Gene Test For Weight Loss

CLOCK Gene Test For Weight Loss

“Let Food Be Thy Medicine and Medicine Be Thy Food”- Hippocrates cited this back in 490 B.C. Science today is pounding over this concept of food based intervention for weight loss specifically tailored to person’s genetic makeup. The research shows that diet shaped according to person’s metabolism may be more effective than non-specialized calorie reduction in helping him or her lose weight i.e. via Nutrigenomics.

Nutrigenomics is the tailoring of one’s diet to their DNA. Personalised Genetic Testing is the key point here, as ONE SIZE FITS ALL concept is not applicable when it comes to your body. Thus, one should revoke the common notion of “WE ARE WHAT WE EAT” and follow the path of “EAT FOR WHO WE ARE”.

“To understand nutrition and health, we need to understand how our unique biology works to keep our body in balance.” This is assessed through our Biological clock also known as CIRCADIAN RHYTHM – The Hero of 2017 Nobel Prize. It involves assessment of individual’s CLOCK gene responsible for timing one’s metabolic activity. Internal biological clocks allow for anticipation of the requirements from body systems at different times of the day and the ability to adapt to changes in external lifestyle factors.

The importance of integration of lifestyle factors, such as timing of eating, activity and sleep with our internal biological clocks is revealed in situations of circadian misalignment that lead to suboptimal health and disease states in the longer term. This concept up lights the path paved towards weight loss. CLOCK gene, affects both the persistence and period of circadian rhythms. Genetic Testing for this gene can help in identifying the CULPRIT for your weight gain. So, buckle up to TIME YOUR FOOD INTAKE AND EXERCISE, TO TIME YOUR WEIGHT LOSS.

Nuclear Bunker: It’s Time to Focus on Your Body Clock!

Nuclear Bunker: It’s Time to Focus on Your Body Clock!

Efforts have been made to decode the working of the biological Body Clock, which often reiterates the age-old nature versus nurture debate. But today’s scientists have conceded that neither nature nor nurture solely can illustrate the molecular mechanism which governs our health. In most of the cases, the predisposition to a health condition is merely due to the presence of a certain gene or a mutation (alteration at the DNA level). This understanding of genes has allowed us to focus on the multifaceted gene-based approach for various health concerns.

Many studies targeting body clock have shown that a disrupted body clock can increase risk towards various health concerns such as diabetes, heart disease, depression etc. A healthy body clock can positively influence the entire health make up. Keeping this in mind a famous project called “Nuclear Bunker” was conducted by BBC–“The Horizon” in association with Ella Al- Shamahi. Where in an army commando Aldo Kane was locked in the nuclear bunker for about 10 days!

So let’s gauge the journey of his 10 days locked up period & how it influenced the body clock….

Locked In A Nuclear Bunker….

You must be thinking why to lock in a bunker that too a nuclear one! Well, it was necessary to keep the commando away from the daylight which directly affects our body circadian rhythm (Biological Body Clock). This way his body clock was controlled using artificial lights available in the bunker.

The Scientific Funda of Body Clock….

The discovery of Body Clock has been marked with Nobel Prize in 2017 to the scientist Jeffrey Hall and Michael Roshbash. Every one of us has a body clock which allows us to march in a 24-hour cycle. This body clock is located near hypothalamus region of our brain (located at the base) which works in response to the day sunlight received. In response to this daylight, different hormones and signals are transmitted throughout the body which regulates this 24-hour rhythm of waking, eating, sleeping, working and continuing the same at fixed timings.

The studies also revealed a gene known as Clock Gene located on Chromosome 4 in human, which regulates the body clock.

Coming back to Nuclear Bunker Experiment….

The study was carried out in 3 phases –

Phase 1 – Where Aldo was left in a bunker and was allowed to follow the normal routine work in absence of daylight.

Phase 2“Going Dim”, Earlier Aldo was able to control the lights but in this phase, he was kept on Dim light mode thus inducing a shift in the body clock.

Phase 3“Jet Lag Mode”, flying through two time zones disrupts the sleep until the next few days due to disruption in body clock. Here Aldo was kept in continuous Jet lag with no break by waking him up before his normal timings.

The observation throughout the Experiment…

Initial phases he was able to keep 24 hr. cycle rather than exceeding for 12 hr. or 36 hr. cycle. This tells that in such excluded environment it was his body clock which kept things to tick on time!

But as soon as he was shifted to phase 3 where there was no daylight, his body entered a “Free Running” stage where his body struggled to keep note of time. Whereas putting back into the normal condition recalibrated his body clock to normal again.

The relevance in today’s lifestyle….

This experiment paved way for the scientist to know more about the CLOCK Gene- The driving force behind your Body Clock. Working according to your body clock can help your body transform into a healthy you! Know your body clock through Clock Gene test & start eating and exercising according to it to experience rapid transformation.

PCOS –Story of Bane to Boon!

PCOS –Story of Bane to Boon!

Don’t give your past the power to define your future”- This thought becomes more prominent among those who stronghold their commitment towards health goals. Have you ever found certain medicine not working for you? Ever wondered why it happens? The answer to this lies within your “Genes”.

Genetics governs the entire health of an individual and tendency towards diseases. PCOS is one such condition with complex hormonal disorder which affects 10 million women globally resulting in most common cause of infertility among women. This is where science of Nutrigenomics paves in, furnishing a more precise and successful treatment using Nutrition and Genetics. We at Genetic Healing work on principle of ‘Let food be thy medicine’. Our team of experts (Nutrigenomic Counsellors) traverses through cases that inflict the mind to bring exorbitant change in someone’s life. One such story of our patient (name not revealed) suffering from PCOS has left its marks in our mind, showing how Nutrigenomics can be highly effective in PCOS management and can be a leap forward in someone’s life.

Now, that you’re all caught up…let’s continue our cognizance over her journey …

The patient in this case study is a female, who is an aspiring doctor. Her struggle started 2 years back when she was diagnosed with PCOS. Irregular periods became new normal for her; she tried to balance it with medicines, but it didn’t relieve her from sufferings completely. Before she met us she was experiencing delayed periods for 6 month which became quite frustrating for her. But winners are those who don’t give up and hence, she took charge of her life and ended up to Genetic Healing. A dedicated team of Nutrigenomist helped her with Pre Test Counselling to suggest her appropriate genetic tests (PCOS PANEL).

Findings from Nutrigenomic test –

As per the Nutrigenomic report it was found that her detoxification genes were carrying a variation due to which both Phase 1 and Phase 2 Detoxification process were inefficient. The genes for Oxidative stress, lipid metabolism, fat gain, Increased BMI were also affected. The most noticing point was, In case of estrogen metabolism some genes were found to be affected which creates problem in elimination and also high impact of environmental factors on estrogen metabolism.

Nutrigenomic Solution –

The main pillar of this case lies with Nutrigenomic Counsellors who gave detailed inputs about her condition. So the genetic test cleared the mirror and helped Nutrigenomist to work on her weaknesses and Strengths based on her Nutrigenomic Report. They gave her a Personalized Diet and Exercise recommendations. She followed recommendations with full dedication and positive results can be seen just after 1 month. In follow up counselling she expressed following response –

I had a very good experience with Genetic Healing. I was suffering from irregular periods with a gap of 6 months but since I have started taking the diet and exercise suggested by Genetic Healing, I am having regular periods. So I am very happy and will definitely recommend this to each and everyone.

This was miraculous for her and though her symptoms were not fully alleviated, they became manageable. This gives an enormous leap forward for this woman’s health and aptness to cope day in and day out. Nothing in this world is more beautiful than helping someone find their true self, allowing them to live their life on their own terms rather being guided by some disorders.

How DNA Testing Can Become The Solution For All Your Dieting Issues

How DNA Testing Can Become The Solution For All Your Dieting Issues

For several years people have been trying to improve their fitness and looks through a variety of diets. Unfortunately, most of these diets fail to deliver on what they promise. This is mostly because every person’s body is very different on a genetic level, which defines their specific nutritional needs. The approach of trying to force your body to a one-size-fits-all diet fails to address these needs appropriately.

Getting your genes tested to gain an exact idea of what your body needs is the best way to see how your body will react to different nutritional inputs, and what food is beneficial or harmful to your body. Centers for DNA testing like Genetic Healing study your genes in detail and help create diet plans that are accurately customized for you. Our technology of international standards helps you to understand your body, which boosts your efforts and efficiency in meeting your fitness goals. Let us understand how nutrients can affect a person, and what a DNA test may reveal about them.

Metabolizing Carbs:
Carbohydrates are essential nutrients that are required to generate energy for all body functions. A gene test can tell you how much of fast carbohydrates (sugar, tubers, soft drinks) and slow carbohydrates (vegetables, greens, legumes, grains) you should consume for your daily dietary requirements. If your body is not inclined towards metabolizing carbohydrates efficiently, a higher proportion of slow carbs can be more beneficial for you, due to their slow release rate of energy.

Chances of Regaining Weight – Your genes can also tell you exactly how fast you can lose or gain weight. This can be understood mainly due to the study of the adiponectin hormone. This hormone is generated by the fat cells and it is responsible for the appropriate utilization of fat from one’s diet to obtain optimal energy. The more adiponectin hormone produced by the body, the more does it help in easing out weight loss and management. Gene testing can tell you exactly what your chances are of regaining weight and can help you create a comprehensive plan for effective weight management.

The critical thing to remember no matter what diet you are following is to primarily focus on 3 major points: reduce the consumption of refined sugars and carbs, increase the number of vegetables you eat, and choosing to eat nutrient filled home-cooked foods as far as possible. Finding a diet that you don’t find too difficult to maintain while meeting all parameters of healthy food is precisely what is needed to sustain the diet for a more extended period, ensuring the success of weight loss and fitness.

The quality of the food choices you make can create a significant impact regardless of how your diet is structured. Satiety is also very important. As far as possible try to eat foods that helped you feel fuller for a more extended period of time.

For more guidance on how you should structure your dietary habits according to your genes, get a gene test done today.

What is Personalized Medicine and How Is it Useful?

What is Personalized Medicine and How Is it Useful?

Personalized medicine is the field of health care of precision in medication, diagnosis, and treatment that are separately designed for every individual, according to their distinct needs, in every way that is possible. Although still in a nascent stage, genetic information of a person can offer a whole lot to patients. This is possible largely due to the Human Genome Project of 2003.

How Genomic Information is Helpful in Developing Personalized Health Care

Each gene in the human body provides information about a protein that is essential for the body. This information can used by health care providers to customize treatment according to the genetic makeup of the body. This can help in improving breakdown, absorption, and effect medications have in the body on a molecular level, through improved targeting of the specific proteins.

Some studies focusing on the effects of drugs, found that people sharing a specific gene variation had similar responses to treatment from specific medications. They all either showed greater inclination towards side effects even at low doses, needs of higher doses for improvement in health, no improvement at all, more improvement than people with other gene variants, or better treatment times.

This is currently being used to improve on treatment for major health issues like HIV, cardiovascular ailments, lung disease, depression, high cholesterol, cancer, etc. As per the genetic makeup of each person modern medications can target specific targets, leaving other areas of the body unaffected, reducing the possibility of side effects, and increasing the effectiveness of the treatments. Identifying the correct genetic variation makes drugs more safe and effective.

At present, the aim of personalized health care is to create medicines that are just enough to address a health issue, but not at a level that may cause adverse side effects. For this purpose, information such as the patient’s height, weight, age, and functioning of vital organs are utilized. The use of genetic information is a recent improvement that has resulted in better accuracy of the appropriate prescriptions and treatment.

Identification of disease related genes can indicate the probability of a person acquiring the disease in the future. In a person is predisposed towards a certain genetic disorder, preventative medication and appropriate lifestyle changes can stop its occurrence from ever coming to fruition.

Although the use of genetics in medicine has shown great promise, it is still in its nascent stages. A whole lot of research and clinical trials are required to correctly recognize the link between genes and specific aliments and treatments, confirming hypotheses to create standardized guidelines. So far, progress in the field indicates that it wont be long before the combination of genetics and health care is a part of mainstream medicine.

At Genetic Healing, we provide world class gene testing facilities, for a wide variety of health issues. If you care about taking your health to the best possible outcome from the basics, get started with our single gene test for just Rs. 999/- at today!

The Secret Behind “Night-Owlness!”

Either you, or someone you know, are what people call “night owls” – individuals who cannot fall asleep at times deemed regular by most. These people suffer from what science calls “delayed sleep phase disorder”. In short, these are people who prefer staying up late and simply hate early mornings.

In a previous post, we’ve already talked about the internal time keeping machine – our biological clock or circadian rhythms – that regulates our body’s response to environmental stimuli, especially light. If the clock is functioning perfectly, every human being on this planet should feel sleepy as night falls and lights dim.

However, scientists have found out that people, whom we call “night owls” carry a mutated form of a gene called CLOCK gene that is an important gene of the biological clock. Scientists studying this phenomenon also found that relatives of such a person also carry this mutation and display a history of sleep problems. It was found that either the sleep pattern in these people had shifted by 2 to 4 hours or had an erratic pattern altogether.

This mutation was found to slow down the biological clock allowing such individuals to have a slower circadian rhythms and a longer circadian cycle. While the distribution of this mutation is still not clearly known, scientists believe that in some populations like the Europeans of non-Finnish descent, this mutation might be present in as many as 75% of people.

But this does not spell doom for people with delayed sleep phase disorders. Information about our genes is a powerful tool for targeted intervention. Similarly, if we have information about these mutations and through history we know that a particular individual has a longer circadian cycle, steps can be taken to regularise sleep patterns.

Mutations in genes of the circadian cycle have many other implications on our health as well. For example, some gene variants make individuals more active as the day progresses. These people are on top of their game in the evenings when other people are looking to wind down after a hectic day’s work. While these people are often seen as anomalies, for them, personally, it is just the way they are.

Also, in many people who feel active in the evenings, their bodies are most receptive to exercising and other physical activities. In fact, these individuals will gain maximum benefit from exercising only if they do it in the evenings. So if such an individual is on a weight loss regime, he or she has to exercise in the evening for maximum benefit. This can be gauged from a simple, painless gene test.

Genetic information is revolutionizing medicare, especially preventive medicare. If we know what our genes have to say, we can use this potent information to stop many chronic and debilitating diseases from happening through the right intervention that focusses on diet and lifestyle modifications. This in turn can amount to savings of millions of rupees in treatments. We have the technological wherewithal backed by solid research and that gene tests will become as common as blood grouping tests is a given.

Any questions? Get a call.